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KMID : 0816120000030010047
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Korean Journal of Pediatric Gastroenterolology and Nutrition
2000 Volume.3 No. 1 p.47 ~ p.55
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Clinical and Histopathologic Findings on the Abnormal Liver Function Complicated with Kawasaki Disease
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Lee Sung-Chul
Na Song-Yi
Tchah Hann
Shin Mi-Kyeong
Park Ho-jin
Kim Hee-Sup
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Abstract
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Purpose : The aim of this research is to examine the abnormal liver function
complicated with Kawasaki disease (KD) and to analyze its clinical characteristics and
complications.
Methods : Ninty eight cases were diagnosed as having KD, among which thirty four
cases had abnormal alanine aminotransferase (ALT) (>30 IU/L). These abnormal ALT
cases were evaluated in terms of age and sex distribution, major symptoms,
complications, laboratory and histopathologic findings.
Results : Male to female ratio was 2.4 : 1 and most patients (91.2%) were under 5
years of age. Cervical lymphadenopathy was observed in 3 cases (8.8%); and recurred
cases were two (5.8%). Average fever duration was 8 days: average length of
hospitalization was 9 days; and average recovery period was 13 days. Immediately after
admission, positive CRP was observed in 31 cases (91.2%), leukocytosis (>10,000/㎣) in
26 cases (76.0%), thrombocytosis (>450,000/㎣) in 7 cases (20.6%), and anemia (<10
gm/dl) in 7 cases (20.6%), respectively. GB hydrops or cholecystitis were noted in 3
cases (8.8%) abnormal ECG finding in 1 case (2.9%), coronary dilatation or aneurysm in
2 cases (5.9%). Liver biopsy was done in four cases and revealed mild infiltration of
lymphocytes on the portal area and mild bile duct proliferations.
Conclusion : The abnormal liver function was noted in 34.7% of KD patients, and
subsided all within one month. But the liver function test should be checked closely in
patients of the abnormal liver function test complicated with KD despite of its good
prognosis.
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KEYWORD
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Kawasaki disease, Alanine aminotransferase (ALT), Histopathologic findings,
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